It has been over a decade since the release of the now classic original edition of Murray's Mathematical Biology. Since then mathematical biology has grown at an astonishing rate and is well established as a distinct discipline. Mathematical modeling is now being applied in every major discipline in the biomedical sciences. Though the field has become increasingly large and specialized, this book remains important as a text that introduces some of the exciting problems that arise in biology and gives some indication of the wide spectrum of questions that modeling can address.