This book is the result of collective endeavor of several noted engineering and computer scientists, mathematicians, medical doctors, physicists, and radiologists. The editors are indebted to all of their efforts and outstanding scientific contributions. The editors are particularly grateful to Drs. Petia Reveda, Alex Falco, Andrew Laine, David Breen, David Chopp, C. C. Lu, Gary Christensen, Dirk Vandermeulen, Aly Farag, Alejandro Frangi, Gilson Antonio Giraldi, Gabor Szekely, Pierre Hellier, Gabor Herman, Ardeshir Coshtasby, Jan Kybic, JeffWeiss, Jean-Claude Klein, Majid Mirmehdi, Maria Kallergi, Yangming Zhu, Sunanda Mitra, Sameer Singh, Alessandro Sarti, Xioping Shen, Calvin R. Maurer, Jr., Yoshinobu Sato, Koon-PongWong, Avdhesh Sharma, Rakesh Sharma, and Chun Yuan and their team members for working with us so closely in meeting all of the deadlines of the book. They would like to express their appreciation to Kluwer Publishers for helping create this invitational handbook. They are particularly thankful to Aaron Johnson, the acquisition editor and Shoshana Sternlicht for their excellent coordination for the book at every stage. Dr. Suri would like to thank Philips Medical Systems, Inc. for the MR datasets and encouragements during his experiments and research. Special thanks are due to Dr. Larry Kasuboski and Dr. Elaine Keeler at Philips Medical Systems, Inc. for their support and motivations. Thanks are also due to his past Ph.D. committee research professors, particularly Professors Linda Shapiro, Robert M. Haralick, Dean Lytle and Arun Somani, for their encouragements.